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2004•Unpublished venueRequires access

The effects of interferon gamma on serum level of IL-4 and SP-A in rat model of pulmoanry fibrosis

Cui She-huai

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Abstract

Objective To study the effect of interferon gamma (IFN-γ) on the development of pulmonry fibrosis induced by bleomycin in rat and the possible underline mechanisms. Methods Rats were randomly divided into 3 groups: normal control group, pulmonary fibrosis group and IFN-γ treated group. On days 1, 3, 7, 14 and 28 after bolemycin treatment, 6 rats were killed and the lungs and serum were collected for histopathologic and electron microscope study, ELISA detection of IL-4 and Western Blotting detection of surfactant protein A (SP-A). Results The degrees of fibrosis, the level of IL-4 and SP-A decreased significantly in IFN-γgroup as compared with the pulmonary fibrosis group.Conclusion IFN-γ has the inhibitory effect on the process of pulmonary fibrosis, its mechanisms maybe relate to balance Th cytokine and decrease lung injury.

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What this paper is about

Objective To study the effect of interferon gamma (IFN-γ) on the development of pulmonry fibrosis induced by bleomycin in rat and the possible underline mechanisms. Methods Rats were randomly divided into 3 groups: normal control group, pulmonary fibrosis group and IFN-γ treated group. On days 1, 3, 7, 14 and 28 after bolemycin treatment, 6 rats were killed and the lungs and serum were collected for histopathologic and electron microscope study, ELISA detection of IL-4 and Western Blotting detection of surfactant protein A (SP-A). Results The degrees of fibrosis, the level of IL-4 and SP-A decreased significantly in IFN-γgroup as compared with the pulmonary fibrosis group.Conclusion IFN-γ has the inhibitory effect on the process of pulmonary fibrosis, its mechanisms maybe relate to balance Th cytokine and decrease lung injury.

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Available abstract

Objective To study the effect of interferon gamma (IFN-γ) on the development of pulmonry fibrosis induced by bleomycin in rat and the possible underline mechanisms. Methods Rats were randomly divided into 3 groups: normal control group, pulmonary fibrosis group and IFN-γ treated group. On days 1, 3, 7, 14 and 28 after bolemycin treatment, 6 rats were killed and the lungs and serum were collected for histopathologic and electron microscope study, ELISA detection of IL-4 and Western Blotting detection of surfactant protein A (SP-A). Results The degrees of fibrosis, the level of IL-4 and SP-A decreased significantly in IFN-γgroup as compared with the pulmonary fibrosis group.Conclusion IFN-γ has the inhibitory effect on the process of pulmonary fibrosis, its mechanisms maybe relate to balance Th cytokine and decrease lung injury.

Key concepts: Bleomycin, Pulmonary fibrosis, Fibrosis, Medicine, Cytokine, Blot, Interferon gamma, Interferon γ

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