2013•Nanjing Xiaozhuang Xueyuan xuebaoRequires access

The Transportation Mode and Mechanism of Mitochondrial Protein

Feng Zhou

Abstract

Mitochondria are the most important organelles in eukaryotic cells.The spatial structure of mitochondria including four regions: outer membrane,inner membrane,intermembrane space and matrix.Mitochondrial transport system comprises the translocase of the outer and inner mitochondrial membrane,soluble factors of the cytoplasm,intermembrane space and matrix.The transportation mechanism of mitochondrial precursor protein into inner membrane,intermembrane space and matrix are emphasized in this paper.The structure and function of translocators including TOM40 complex,TIM23 complex,small Tim proteins and the disulfide relay system are also discussed in the present paper.

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Key concepts: Intermembrane space, Translocase of the inner membrane, Translocase of the outer membrane, Mitochondrial intermembrane space, Mitochondrial carrier, Mitochondrial membrane transport protein, Cell biology, Inner mitochondrial membrane