Effect of Atorvastatinon Postprandial Serum Triglyceride Metabolism and Endothelial Function in Hypertensive Patients

Objective To investigate effect of atorvastatinon postprandial abnormal serum triglyceride metabolismand endothelial function in hypertensive patients(HT). Methods Thirty hypertensive patients with abnormal triglyceride metabolism after a standardized fat loading were recruited. Endothlium-dependant flowing-mediated dilation(EDF) was assessed by doppler flow in the brachial artery before and 4 hours after fat loading. Patients were randomly divided into conventional group and atorvastatingroup (20 mg per night for 4 weeks). After treatment, the standardized fatmeal test and endothelial function examination were repeated. Results The postprandial EDF in two groups were impaired significantly at 4 hours (P0.05). There were no difference in TG-AUC and TGPR between conventional group and atorvastatingroup. After 4 weeks the blood pressure in both groups significantly were decreased. The TG-AUC, TGPR, fasting EDF and postprandial EDF in atorvastatingroup was improved obviously [TG-AUC: (18.84±6.81 vs 10.12±5.38)mmol/L, P 0.05; TGPR: (3.96±1.78 vs 2.16±1.06)mmol/L, P 0.05; fasting EDF: 3.89%±3.28% vs 17.96%±3.87%,P0.05; postprandial EDF: 9.88%±3.53%vs 16.67%±3.35%,P0.05)]. No difference between fasting EDF and postprandial EDF in atorvastatin group was shown. On contrary, no significant change in the TG-AUC,TGPR, fasting EDF was found in conventional group after 4 weeks conventional treatment, and the postprandial EDF was even obviously aggravated after 4 weeks. Correlation analysis showed SBP, DBP and the changes of fasting EDF were correlated with TG-AUC and TGPR (P0.05). Conclusion Atorvastatinlipid-modulating therapy can effectively improve serum triglyceride metabolismand endothelial function in hypertensive patients.