The study on lymphocytes apoptosis and expression of CD11b in severe pediatric pneumonia

Objective:To explore significance of lymphocytes apoptosis and expression of CD11b in severe pediatric pneumonia.Methods:Early apoptosis rate,end stage apoptosis and death rate,expression of CD11b of peripherial blood lymphocytes in acute period and recovered period were measured with flow cytometry in 22 cases of severe pediatric pneumonia,compared with 21 cases of mild pneumonia and 20 cases of normal children.Results:In acute period,early apoptosis rate,end stage apoptosis and death rate of peripherial blood lymphocytes in severe pediatric pneumonia were(19.76±13.87)% and(6.16±6.6)%,Respectively,both of them were higher than that of control group((4.59±1.25)%,(0.13±0.06)%),(t=15.46,P0.001;t=12.83,P0.001).CD11b of lymphocytes was(6.21±2.09)%,it was lower than that of mild pneumonia group((20.75±6.16)%) and normal children group((12.43±3.4)%)respectively,(t=9.49,P0.01,t=7.59,P0.01).In recovered period of severe pediatric pneumonia,early apoptosis rate was(16.56±13.6)%,while end stage apoptosis and death rate was(2.79±2.81)%.Both of them were higher than that of control group((6.6±1.9)%,(1.43±1.58)%),(t=3.32,P0.01,t=2.03,P0.05).CD11b of lymphocytes was(10.97±2.32)%,They were higher than that acute in period(t=7.22,P0.01).Conclusion:The peripherial blood lymphocytes apoptosis and expression of CD11b takes a contain effect during the prognosis of severe pediatric pneumonia.