Three-dimensional conformal Hypofractionated Radiotherapy combined with TP Regimen for Treatment of Senile Locally Advanced Non-small Cell Lung Cancer

Objective To evaluate the clinical efficacy and toxicity of three-dimension conformal radiotherapy sequential TP regimen for treatment of elderly patients with locally advanced non-small cell lung cancer.Methods 46 case of elderly patients with locally advanced NSCLC were treated by three-dimension conformal hypofractionated high dose radiotherapy: total dose from 40 to 64Gy,6 to 8Gy for each fraction,3f/W.TP regimen(docetaxel 75 mg/m2,d1 and carboplatin 300 mg/m2,d1,21-28 days was a cycle) followed 1-2 weeks after 3DCRT.Each patient should complete no less than two cycles’ chemotherapy.The response and toxicity were evaluate and survival rats was followed up.Results The toal response rate was 89.1%.The 1-,2-and3year survival rats was 82.6%,47.8%,and 26.1%.The main toxicities were local radiation pneumonia(17.4%),radiation esophagitis(8.7%),leucopenia(73.9%),and nausea/vomiting(21.7%),mainly grade 1-2.Conclusion The three dimensional conformal hypofractionated high dose radiotherapy sequential TP regimen for elderly patients with locally advanced NSCLC is effective.The toxicities are mild,It is worthy of further study.