Epidural tramadol and midazolam injection for the analgesia after abdominal operation

Aim:To observe the analgesic effect and adverse reaction of epidural tramadol and midazolam injection, and the influence on hemodynamic and respiration in patients after abdominal operation. Methods: A total of 40 patients (ASAⅠ～Ⅱ, undergoing elective middle and low abdominal operations) were randomly divided into 2 groups: GroupⅠ (tramadol and midazolam group, n =20) and GroupⅡ ( tramadol group, n =20). When closing the abdominal cavity, 10 ml analgesic solution in 2 groups was slowly injected to epidural space. In GroupⅠ,tramadol 100 mg and midazolam 2.5 mg were diluted with normol saline, while in GroupⅡtramadol 100 mg diluted. The changes of p MA , f H, x O 2 , f R and ECG at 10 min, 20 min and 30 min after injection were observed. The analgesic effect was assessed with Prince Hennry scale. The analgesic time and adverse reactions were also recorded. Results: In Group I and Ⅱ, the analgesic scores were (1.25±1.10) and (1.75±1.12) respectively. The remission rates of pain were 85% and 75% respectively. The analgesic time of Gronp Ⅰ was markedly longer than that of Group Ⅱ( P 0 1). In 2 groups, the p MA , f H, x O 2 , f R and ECG had no significant differences compared with those before injection ( P 0.05). The pulmonary complications and arrhythmia hadn't found in all patients. Conclusion: The analgesic effect of epidural tramadol and midazolam injection is definate. The functions of respiration and circulation of patients are all stable. This analgesic method is safe and effective for postoperative pain.