Effects of hypertonic saline on delayed resuscitation of severely burned patients

Objective To investigate the effects of hypertonic saline in delayed resuscitation of burn shock patients.Methods Thirty-one recruited patients were divided into two groups:hypertonic saline group and balanced saline group.Laboratory results (K~+,Na~+,Cl~+),resuscitation fluid volume and urine output in first 24 hours and second 24 hours were observed.Results During the first 24 hours,resuscitation fluid volume and urine output were 1.52±0.15 ml/(kg·1%TBSA),0.94±0.12 ml/(kg·1%TBSA) in the hypertonic saline group,and 1.74±0.26 ml/(kg·1%TBSA),1.24±0.30 ml/(kg·1%TBSA) in the balanced saline group,respectively,with significant difference(P0.05).During the second 24 hours,resuscitation fluid volume and urine output were 1.21±0.14 ml/(kg·1%TBSA),1.18±0.15 ml/(kg·1%TBSA) in the hypertonic saline group,and 1.47±0.21 ml/(kg·1% TBSA),1.40±0.30 ml/(kg·1%TBSA) in the balanced saline group,respectively,with significant difference was found(P0.05).Changes in laboratory results(K~+,Na~+,Cl~+) before therapy and after 24 hours and 48 hours,have no significant difference between the two groups(P0.05).Conclusion Hypertonic saline resuscitation is similar in effect of recovery to balanced saline resuscitation, but has less fluid requirement than balanced saline resuscitation;it has obvious clinical value.