2010•Chinese Journal of New Drugs and Clinical RemediesRequires access

Effects of zolpidem on polysomnography in patients with insomnia

Lou Meizhen, Xingshi Chen, Lou Feiying, Wu Yi, Ma Shuntian, Wang Zucheng

Abstract

AIM:To observe the effects of zolpidem on polysomnography (PSG) in patients with insomnia.METHODS:Twenty-six patients with insomnia received PSG in three consecutive night and received zolpidem 20 mg before sleep on night 3.Thirty-three normal subjects received PSG on an adaptation night and a baseline night.RESULTS:Compared with baseline night,sleep efficiency of patients with insomnia improved (P0.05),awakening time reduced (P0.01),stage 1 time decreased (P0.01),stage 2 time increased (P0.01 ),sleep latency shortened (P0.01) on night 3.CONCLUSION:Zolpidem has effects on PSG in patients with insomnia.

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Key concepts: Zolpidem, Polysomnography, Insomnia, Medicine, Anesthesia, Sleep (system call), Hypnotic, Chronic insomnia