Expression of c-erbB-2 Proteins and PCNA in Pancreatic Adenocarcinoma and its Clinical Significance

Objective To investigate the expression of the c-erbB-2, PCNA and the clinicobiological behavior in human pancreatic adenocarcinoma. Methods The expression of c-erbB-2 and PCNA in 39 cases of human pancreatic adenocarcinoma were investigated with immunohistochemistry of avidin-biotin complex. Results In the 39 cases with pancreatic ductal adenocarcinoma, the positive rate of c-erbB-2 proteins was 46.15%, The PCNA LI was 27.54±16.42. The positive rate of c-erbB-2 were related to the histological grade (P0.05) but not to clinical stages (P0.05). The PCNA labeling index were significant difference in histological grades and clinical stages (P0.01). The expression of c-erbB-2 and PCNA were positively correlated with lymph node metastasis. The expression of c-erbB-2 was not related to the PCNA (P0.05). Conclusion The expression of c-erbB-2 and PCNA are important markers reflecting the biological behaviors and prognosis of pancreatic carcinoma.