Observation of Serum Lipid and Histopathology in ApoE Gene Knockout Mice

Objective To oberseve the serum lipid and histopathology in ApoE gene knockout mice. Methods 24 ApoE gene knockout mice(bisexual each half) were selected,using 24 C57BL/6J mice as controls,to oberseve TC,LDL,HDL and the change of heart pathological morphology. Results The TC,LDL level of ApoE gene knockout mice were significantly higher than in control groups(P 0.05);the HDL level had no significantly difference in both groups;the area of atherosclerotic plaque of ApoE gene knockout mice was significantly higher than in control groups(P 0.05);there was clinical occurrence of atherosclerosisin ApoE gene knockout mice. Conclusion ApoE gene knockout mice promotes atherosclerosis easily.