Comparision of remifentanil or fentanil in pediatric patients undergoing palatorrhaphy

Objective To compare the clinical efficiacy and safety of remifentanil with that of fentanyl in pediatric patients undergoing palatorrhaphy under general anesthesia. Methods 70 ASAI~Ⅱ pediatric patients aged 1～5 years old undergoing palatorrhaphy were enrolled and randomized into remifentanil group(group R) and fentanyl group (group F). Each group consisted of 35 cases. Anesthesia was induced with propofol (2.0 mg/kg),plus either remifentanil (1.5 μg/kg) or fentanyl (2.0 μg/kg),and maintained with inhalation of 0.75~1.0 vol% sevoflurane,plus a continous infusion of either remifentanil 0.20 μg/(kg·min) or fentanyl 0.08 μg/(kg·min). The intraoperative hemodynamic parameters and recovery profile were compared. Results Hemodynamic values during induction,tracheal intubation and skin incision were significantly lower as compared with preoperative(P 0.01,P 0.05). HR was significantly lower at tracheal intubation,and higher at tracheal extubation in group R than those in group F(P 0.05). Quicker conscious recovery and less complications could be detected in group R in contrast with group F(P 0.05). Conclusions Remifentanil-based general anesthesia presents more safety and efficacy than fentanyl-based anesthesia in pediatric patients undergoing palatorrhaphy.