2015•International Journal of Cardiovascular DiseaseRequires access
Association of blood pressure circadian rhythm and variability with atherosclerosis in patients with essential hypertension
Ni Q
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Abstract
Objective:To investigate the association of blood pressure circadian rhythm and variability with atherosclerosis in patients with essential hypertension. Methods:120 patients diagnosed as essential hypertension were divided into dipper group(n=22),non-dipper group(n=36)and reverse dipper group(n=62)according to the circadian rhythm determined by ambulatory blood pressure monitoring(ABPM).Blood pressure variability and the incidences of coronary heart disease and carotid atherosclerosis in three groups were analyzed. Results:24 hours systolic blood pressure standard difference(24hSSD),24 hours diastolic blood pressure standard difference(24hDSD),day systolic blood pressure standard difference(dSSD),day diastolic blood pressure standard difference(dDSD),24 hours systolic blood pressure coefficient of variation(24hSBP-CV)and night systolic blood pressure coefficient of variation(nSBP-CV)in reverse dipper group were lower than those in dipper group(P0.05)while24hDSD,dDSD,24 hours diastolic blood pressure coefficient of variation(24hDBP-CV)in reverse dipper group were lower than those in non-dipper group(P0.05).The incidences of coronary heart disease and carotid atherosclerosis in reverse dipper group were higher than those in dipper group(P0.05). Conclusion:Abnormal blood pressure circadian rhythm could contribute to the development of carotid atherosclerosis in patients with essential hypertension.