2011•Zhongguo yaofangRequires access
Influence of Terazosin on Plasma Concentration of Levofloxacin in Rats with Bacterial Prostatitis
Jun Zhao, HE Hai-xia
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Abstract
OBJECTIVE: To study the influence of terazosin on plasma concentration of levofloxacin in rats with bacterial prostatitis, and to discuss the corporation mechanism of terazosin and levofloxacin. METHODS: Bacterial prostatitis model had been established and randomly divided rats into experimental group and control group (n=60). Experimental group was given terazosin 0.44 mg·kg-1 for oral administration and control group was given solvent. Both groups were given drugs once more after 12 h and injected with levofloxacin 44 mg·kg-1 immediately. Plasma sample was collected 1, 3, 7.5, 15, 30, 60, 120, 240, 480 and 720 min after administration. The plasma concentration of levofloxacin was detected by HPLC. RESULTS: There was no significant difference in plasma concentration of levofloxacin between two groups (P0.05). CONCLUSION: Terazosin has no significant influence on plasma concentration of levofloxacin in rats with bacterial prostatitis, and terazosin improves the effect of levofloxacin on prostatitis by increasing the concentration of levofloxacin in tissue not in plasma.