Clinical study on different doses of urokinase in patients with acute myocardial infarction

Objective:To investigate the effects and adverse bleeding actions of different doses with intravenous urokinase in acute myocardial infarction(AMI).Methods:96 cases of AMI patients were randomly divided into two groups,48 cases in each group.The observation group was treated with intravenous urokinase 6×105 U in 100 ml of 5% glucose in 30 minutes and the control group with intravenous urokinase 1.5×106 U.Other treatment in patients of the two groups was correspondence.Results:The rate of reperfusion,reinfarction,severe complications and mortality had no statistical significance between the two groups(P0.05).But the bleeding rate of the observation group was lower than that of the control group(P0.01).Conclusion:AMI patients treated with intravenous urokinase 6×105 U is safe.