ScholarLens Back to search
2006•International Journal of ImmunologyRequires access

Phospholipase D and Tumor

Wang Ya-xiong

Open publisher page 0 citations

Abstract

Phospholipase D (PLD) is an important signaling molecule,which can hydrolyse phosphatidylcholine (PC) into phosphatidic acid (PA) and choline.Furthermore,PA and its hydrolysis product,diacylglycerol (DAG),are important lipid second messengers.Hence,the activition of PLD involves in multiple signling pathways.A large body of evidence indicates that the activity of PLD is significantly increased in a variety of tumours and PLD is tightly involved in biological behaviors of tumor cells.

About this research paper

What this paper is about

Phospholipase D (PLD) is an important signaling molecule,which can hydrolyse phosphatidylcholine (PC) into phosphatidic acid (PA) and choline.Furthermore,PA and its hydrolysis product,diacylglycerol (DAG),are important lipid second messengers.Hence,the activition of PLD involves in multiple signling pathways.A large body of evidence indicates that the activity of PLD is significantly increased in a variety of tumours and PLD is tightly involved in biological behaviors of tumor cells.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Phospholipase D (PLD) is an important signaling molecule,which can hydrolyse phosphatidylcholine (PC) into phosphatidic acid (PA) and choline.Furthermore,PA and its hydrolysis product,diacylglycerol (DAG),are important lipid second messengers.Hence,the activition of PLD involves in multiple signling pathways.A large body of evidence indicates that the activity of PLD is significantly increased in a variety of tumours and PLD is tightly involved in biological behaviors of tumor cells.

Key concepts: Phosphatidic acid, Phospholipase D, Diacylglycerol kinase, Second messenger system, Phosphatidylcholine, Phospholipase, PLD2, Lipid signaling

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Phospholipase D and Tumor — Research Paper | ScholarLens