The study of correlation between high-risk HPV viral load and cervical lesions and cervical cancer.

Objective To understand the correlation of high-risk human papillomavirus( HPV) viral load and cervical lesions and cervical cancer,looking for HPV-positive cut-off point to lead high-grade cervical lesions and cervical cancer.Methods Highrisk HPV-DNA was detected in more than twenty thousand women in Kunming area by HCⅡ( secondgeneration hybrid capture) method,multiple biopsy under colposcopy sent to pathological examination of 3446 cases of HPV-positive,of CIN( cervical intraepithelial neoplasia) cases with cervical conization to inspect results,cervical cancer patients with postoperative disease inspection subject. Results It was found that of HPV viral load 1 ~ 10, 10 ~ 100,100 ~ 1000, 1000 ~ 10000 RLU / CO,the risk of CIN Ⅰ was 1. 00,1. 387,1. 879,1. 563; more than CIN Ⅱ lesions was1. 00,2. 214,7. 839,12. 90,cervical cancer was 1. 00,6. 949,5. 416,8. 736; HPV viral load predicts high-grade cervical lesions,receive operating characteristic curve( ROC) area was 0. 72,which was high degree of diagnostic value,when HPV load was 100RLU / CO,the sensitivity of high-grade cervical lesions was 75. 6% and specificity was 62. 7%. Conclusion The level of risk of cervical lesions caused by different viral load,that causes cervical cancer risk no significant differences. HPV viral load can be used as indicators of diagnosis of CIN II above lesions,when load was 100RLU / CO,leading to the positive cut-off point for high-grade cervical lesions.