Influence of Metabolic Syndrome on the Left Ventricular Hypertrophy in Hypertensive Patients

Objective To evaluate the influence of metabolic syndrome(MS) on the left ventricular hypertrophy in non-diabetic hypertensive patients.Methods A total of 321 essential hypertensives were included in which 134 patients were diagnosed as MS(EH+MS),187 patients with hypertension alone(EH) as controls.Left ventricular mass index(LVMI) and relative wall thickness(RWT) were determined by echocardiography.Results Compared with hypertension alone(EH) patients,hypertensive patients with MS(EH±MS) were shown to have greater end-diastolic left ventricular internal dimension(LVEDd),end-diastolic interventricular septum thickness (IVSD),end-diastolic posterior wall thickness(LVPWd) and left ventricular mass indexed(LVMI)(P0.01),indicating more prevalent of LVH(EH±MS:26.1%vs EH:11.2%,P0.01).Prevalence of normal left ventricular geometry(NG) was lower in EH±MS(EH+MS:11.9%vsEH:26.7%,P0.05) while the incidence rate of ventricular concentric hypertrophy(CCH) was significantly higher(EH+MS:20.2%vs EH:8.6%,P0.05). No significant difference was found in ventricular concentric remodeling(CCR) and ventricular eccentric hypertrophy (ECH) between these two groups(P0.05).Left ventricular mass index(LVMI) was strongly related with waist circumstance(r=0.692,P0.01).Conclusion Metabolic syndrome is associated with left ventricular hypertrophy (LVH) in hypertensive patients.Abdominal obesity and BP are the 2 independent risk factors of LVH. Therefore,to prevent and reverse the progress of LVH'effectively,it is necessary to not only reduces the abnormal high blood pressure,but also all the risk factors involved by MS is strongly advocated.