The Effect of ChuanFuKang Mixture on Histological Changes of the Airway Remodeling in Asthmatic Rat

Objective To observe the effect of ChuanFuKang mixture on histological changes of airway remodeling of rat models of asthma.Methods An animal model of asthma was established by OVA(ovalbumin) sensitizing-challenging SD rat.Water extract of ChuanFuKang were given to rat(ig).The thickness of bronchial wall and area of collagen deposition were detected by computer image analyse system and Masson trichrome staining.Results The results of the image analysis showed that the thickness of bronchial smooth muscle area of collagen deposition obviously increased,which was more evident in the four-week group than in the three-week group,there was significant difference compared with that of control group(P0.05).The change of hormone group and ChuanFuKang group was not evident,which was no significant difference compared with that of control group(P0.05).Conclusions ChuanFuKang mixture can reduce the airway remodeling by inhibiting the histological changes of rat models of asthma.