Clinical Study of Autologous Peripheral Blood Stem-cell Transplantation for Treatment of Malignant Lymphoma

Objective To evaluate the initial therapeutic effect of autologous peripheral blood stem-cell transplantation(APBSCT) after the routine chemotherapy on malignant lymphoma.Methods Fifty two cases of malignant lymphoma were randomly divided into two groups,control group and transplantation group.The control group(26 cases) was treated with six courses of CHOP or COMP or VDLP or ABVD plan,the transplantation group(26 cases) was treated with APBSCT after six-course routine chemotherapy.Hematopoietic stem cells were mobilized and collected by granulocyte colony stimulating factor(G-CSF) combined with high-dose cyclophosphamide(HD-CTX).The conditioning regimen was CBV.Results Twenty six cases were engrafted and hematopoietic reconstitution was rapid:The mean days of ANC recovery up to 0.5×109/L and Plt up to 20×109/L were 10 days and 13 days,respectively.Complete remission(CR) rate of transplantation group was 80.77% and that of control group was 34.62%;Overall response rate:92.31% vs 61.54%,the efficacy of transplantation group was better than that of control group(P0.05).The follow-up lasted for 6-76 months.The 3-year event free survival(EFS) rates of transplantation group and control group were 83.33%(15/18) and 37.50%(6/16),respectively;The 5-year EFS rates were 58.33%(7/12) and 23.08%(3/13),respectively.The 3-year,5-year EFS rate of transplantation group were higher than those of control group(P0.05).Recurrence rate of transplantation group was lower than that of control group(19.23% vs 46.15%,P0.05).Conclusion APBSCT has better effect than chemotherapy alone for the post-remission treatment of malignant lymphoma,and its recurrence rate is lower than that of chemotherapy alone.