A Clinicopathological Study of 186 Adult Cases with IgA Nephropathy Diagnosed by Renal Biopsy

Objective To investigate the clinical features,histopathology and clinicopathological correlation in 186 adult cases with IgA nephropathy(IgAN) retrospectively. Methods 186 adult cases of IgA nephropathy were divided into two groups according to their age,and the clinical and renal pathological features were analyzed. Results Asymptomatic hematuria with or without the presence of proteinuria was the most common clinical manifestation(65.6%),followed by chronic nephritis(15.1%) and nephritic syndrome(13.4%) Higher incidence of nephrotic syndrome and acute renal failure was found in elder group(50-68years). Pathologically,focal segmental glomerulosclerosis(FSGS)was the most frequent type(36%),followed by mesangial proliferative glomerulosclerosis(MsPGN,25.3%)and minimal lesion(ML,18.8%) among the 186 adult patients with IgAN. Conclusions The relation between the clinical manifestation and pathomorphological type of IgAN is complicated. Asymptomatic hematuria with or without the presence of proteinuria is the most common clinical manifestation and focal segmental glomerular lesion is the most common pathomorphological type of IgAN.