2009•Chinese Journal of Birth Health & HeredityRequires access

Research advances of molecular genetics on dentin dysplasia and dentinogenesis imperfecta.

Yu‐Feng Huang

Abstract

In recent years,substantial progress has been made regarding dentin diseases.These diseases have been classified into two major groups with subtypes:dentin dysplasia(DD) types Ⅰ and Ⅱ and dentinogenesis imperfecta(DGI) types I-Ⅲ.Genetic linkage studies have identified the critical loci for DD-Ⅱ,DGI-Ⅱ and DGI-Ⅲ to human chromosome 4q,which include secreted phosphoprotein 1(SPP1),bone sialoprotein(BSP),matrix extracellular phosphoglycoprotein(MEPE),dentin matrix protein 1(DMP1) and dentin sialophosphoprotein(DSPP) genes.To date,only DSPP mutations have been identified.Now,the newest advances are reviewed.

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Key concepts: Dentin sialophosphoprotein, Dentinogenesis imperfecta, DMP1, Dentin, Bone sialoprotein, Dentinogenesis, Genetics, Osteogenesis imperfecta