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Antidepressant Effect of Seabuckthorn Seed Oil

Tian Jun-shen

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Abstract

The effect of seabuckthorn seed oil on the immobility time in mice was investigated by tail suspension test(TST) and forced swimming test(FST). Body weight, sucrose preference and open-field activities were conducted on mice with depression induced by chronic unpredictable mild stress(CUMS) to explore the antidepressant effect of seabuckthorn seed oil. The results showed that administration of seabuckthorn seed oil was capable of reducing the immobility time in FST and TST while other indices such as body weight, sucrose preference, open-field activities were increased significantly(P 0.05, 0.01). These findings implicated that seabuckthorn seed oil might be a potential antidepressant for developing functional foods or drugs.

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What this paper is about

The effect of seabuckthorn seed oil on the immobility time in mice was investigated by tail suspension test(TST) and forced swimming test(FST). Body weight, sucrose preference and open-field activities were conducted on mice with depression induced by chronic unpredictable mild stress(CUMS) to explore the antidepressant effect of seabuckthorn seed oil. The results showed that administration of seabuckthorn seed oil was capable of reducing the immobility time in FST and TST while other indices such as body weight, sucrose preference, open-field activities were increased significantly(P 0.05, 0.01). These findings implicated that seabuckthorn seed oil might be a potential antidepressant for developing functional foods or drugs.

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Available abstract

The effect of seabuckthorn seed oil on the immobility time in mice was investigated by tail suspension test(TST) and forced swimming test(FST). Body weight, sucrose preference and open-field activities were conducted on mice with depression induced by chronic unpredictable mild stress(CUMS) to explore the antidepressant effect of seabuckthorn seed oil. The results showed that administration of seabuckthorn seed oil was capable of reducing the immobility time in FST and TST while other indices such as body weight, sucrose preference, open-field activities were increased significantly(P 0.05, 0.01). These findings implicated that seabuckthorn seed oil might be a potential antidepressant for developing functional foods or drugs.

Key concepts: Behavioural despair test, Open field, Tail suspension test, Sucrose, Antidepressant, Body weight, Traditional medicine, Food science

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