2003•Journal of Jiangsu Clinical MedicineRequires access

THE EFFECT OF BRAIN TISSUE SITE PERFUSION WITH MANNITOL ON CEREBRAL EDEMA AFTER BRAIN INJURY IN RABBITS

Zhi Zhang

Abstract

Objective: To study the role of Mannitol on cerebral edema and brain damage after brain injury by local treatment. Methods: An rabbit model with brain injury was conducted to contusion by bone windowplasty with extradural hitting.The treated group was dealt with by local rinsing of 20% Mannitol,The control group was not treated accordingly and then the rabbits were killed in ordered time.The changes of moisture in brain tissues and serum myelin basic protein(MBP) were observed. Results: The percent of water content and MBP in the treated group were lower than those of the control group. Conclusions: Local using of Mannitol has an therapeutical effect on the secondary cerebral edema.ylocaltreatment.Methods:

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Key concepts: Mannitol, Medicine, Brain edema, Cerebral edema, Edema, Anesthesia, Myelin, Cerebral perfusion pressure