2013•Zhonghua zhongliu fangzhi zazhiRequires access
Expression and role of Caspase-9 in thyroid carcinoma and thyroid benign tumor
YU Yao-jun
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Abstract
OBJECTIVE:To investigate the expression of Caspase-9 in thyroid carcinoma and thyroid benign tumor and to analyze clinical signficance.METHODS: The expression of Caspase-9 protein was detected with immunohistochemical Enision TM plus non-hiotin technique in 65 cases of thyroid carcinoma and 40 cases of thyroid benign tumor as well as normal tissues.RESULTS: The positive expression rates of Caspase-9 protein in thyroid carcinoma,thyroid benign tumor and normal tissues were 21.5%(14/65),50.0%(20/40),85.0%(34/40).There was significantly different among three groups(χ2=7.65,P0.01).The expression of Caspase-9 were positively related to AJCC clinical stage,differentiation degree,lymph node metascasis and the degree of infiltration(χ2 were 6.39,7.08,8.17 and 9.25,all P0.01).CONCLUSION: The low expression of Caspase-9 protein may play important roles in the carcinogenesis of thyroid carcinoma and it is involved in the metastasis and infiltration.