Contrast of the adverse drug reactions to the treatment of rheumatoid arthritis with combination of nabumetone or naproxen and methotrexate

AIM Contrast of the adverse drug reaction to the treatment of patients with rheumatoid arthritis by combination of nabumetone (NAB) or naproxen (NAP) and methotrexate (MTX). METHODS By questionnaires among the two groups taking nabumetone plus methotrexate or naproxen plus methotrexate respectively, meanwhile, consulting their medical records and their various lab test reports. All these data were figured out and analyzed by Epi info.RESULT After treatment of illnesses, there is no obvious difference ( P 0 05) except in the case of stomachache ( P 0 05) among the two groups.CONCLUSION There is no indication that COX-2 alternative inhibitor NAB combined with MTX is superior to NAP combined with MTX in adverse drug reactions.