Menopause and cognitive dysfunction

Cognitive dysfunction refers to various degrees of cognitive impairment caused by many reasons.The cognitive decline in elderly female is not only related to factors such as age and genetic susceptibility,but also interrelate with the lack of endogenous estrogen because of menopause.The neuroprotective effect of estrogen has been demonstrated in many laboratory studies and animal studies,but in clinical application,the effect of hormone replacement therapy(HRT) is not entirely consistent with expectations.This may be related to the initiation timing of HRT.Currently,it is accounted that the benefit for long-term protective effect on dementia could beachieved if HRT is prescribed during the therapeutic window near menopause.