Multiple factors analysis of recurrence and metastasis following radical surgery for colorectal cancer

Objective:This study was to investigate the clinicopathologic factors related to recurrence and metastasis following curative surgery for colorectal cancer,in order to improve the treatment effects.Method:The clinicopathologic factors and follow-up data of 455 cases of colorectal cancers after surgical treatment from 1995 to 2003 were retrospectively analyzed by univariate and multivariate methods.Results:Univariate analysis showed that tumor location,tumor size,Dukes' stage,lymph node metastasis and histological differentiation were significantly associated with recurrence and metastasis.Multivariate analysis showed that tumor location and Dukes' stage were prognostic factors for recurrence and metastasis after operation.In separate analysis of distant metastasis and local recurrence with multivariate method,lymph node metastasis and tumor location were closely related to local recurrence.Dukes'stage was related to distant metastasis.Conclusions:Tumor location and Dukes' stage are important risk factors for recurrence and metastasis after radical surgery for the patients with colorectal carcinoma.Dukes' stage is an important prognostic factor for distant metastasis.The patients with rectal cancer associated with lymph node metastasis should be considered to have additional risks for local recurrence.