Experimental study on tumor angiogenesis inhibition effect of new angiogenesis peptide (chiral preparation)

Objective To observe the effect of a new angiogenesis peptide on tumor and possible mechanism.Methods The MTT assay and endothelial cell migration methods were used for the test of drug-effect in vitro and subcutaneous inoculation C57BL/6N with Lewis carcinoma of lung oncocyte for vivo growth condition.Results There is the obvious inhibitional effect on propagation endothelial cell propagation and migration, and obvious volume miniture and capillary blood vessel rarus were observed at Lewis carcinoma of lung subcutaneous oncocyte in vivo.Conclusions The new angiogenesis peptide possible obvious inhibites Lewis tumor growth ,the mechanism may correlate to inhibition on tumor angiogenesis.