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Research Progress of Cx43 Phosphorylations

Yan Jia

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Abstract

Gap junction( GJ) is the most main and rapid communication way between adjacent cells,which is composed by connexin( Cx). Connexins mostly belong to the phosphoprotein. The phosphorylation status influences its own synthesis assembly and the function of the GJ. Cx43 is the most widely distributed connexin in mammals,especially in the cardiovascular system and nervous system. Various kinases involved in the regulation of Cx43 phosphorylation,and phosphorylation site is different,and the Cx43 phosphorylation is involved in a variety of disease development.

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What this paper is about

Gap junction( GJ) is the most main and rapid communication way between adjacent cells,which is composed by connexin( Cx). Connexins mostly belong to the phosphoprotein. The phosphorylation status influences its own synthesis assembly and the function of the GJ. Cx43 is the most widely distributed connexin in mammals,especially in the cardiovascular system and nervous system. Various kinases involved in the regulation of Cx43 phosphorylation,and phosphorylation site is different,and the Cx43 phosphorylation is involved in a variety of disease development.

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Available abstract

Gap junction( GJ) is the most main and rapid communication way between adjacent cells,which is composed by connexin( Cx). Connexins mostly belong to the phosphoprotein. The phosphorylation status influences its own synthesis assembly and the function of the GJ. Cx43 is the most widely distributed connexin in mammals,especially in the cardiovascular system and nervous system. Various kinases involved in the regulation of Cx43 phosphorylation,and phosphorylation site is different,and the Cx43 phosphorylation is involved in a variety of disease development.

Key concepts: Connexin, Phosphorylation, Phosphoprotein, Gap junction, Kinase, Cell biology, Function (biology), Protein phosphorylation

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