Propofol Combined Remifentanil for Total Intravenous Anesthesia in Orthopedic Surgery

Objective To explore the clinical usage of propofol combined with remifentanil for total intravenous anesthesia in orthopedic surgery.Methods 260 patients were randomized into two groups(group A and B,n=130 in each group).Propofol 1.0mg/kg and remifentanil 1.5μg/kg were used for anesthesia induction and then propofol(4～8)mg/(kg·h) and remifentanil(0.1～0.8)μg/(kg·min) were used during the maintaining in A group.Propofol 1.0mg/kg and 1.5μg/kg of fentany were used for anesthesia induction and then propofol(4～8)mg/(kg·h) and 0.15μg/(kg·min) were used during the maintaining in B group.HR,SBP,DBP before and after tracheal intubation and operation,pain reaction were record,as well as the waking time,OAAS,the total dosage of propofol and adverse reaction.Results Before and after tracheal intubation,and during the operation,the value of SBP and DBP were lower in A group than in B group(P0.05).The time for patiens to wake up and tube drawing was longer in B group than in A group,and the total dosage of propofol was used much more in B group(P0.05).However,the scores of OAAS were almost the same,and no pain reaction appeared in the two groups.In addition,the incidence of adverse reaction was relatively low.Conclusion Propofol combined remifentanil is safe and effective in total intravenous anesthesia in orthopedic surgery.