Effects of sulodexide plus irbesartan on renal function and uric protein in hypertensive patients with renal impairment

Objective To observe the effects of the combination therapy of sulodexide and irbesartan on renal function and uric protein in hypertensive patients with renal impairment.Methods In total,66senile hypertensive patients with renal impairment were randomly divided into control group(n=33,routine treated with irbesartan 150mg/d)and combined treatment group(n=33,routine treated with sulodexide 250LSU,bid and irbesartan 150mg/d).After 12weeks,blood pressure,serum creatinine,cystatin C,urine microalbumin,α1-microglobulin and urineβ2-microglobulin were measured and compared between the two groups.Results Compared with those before the study,there were no significantly changes in erumcreatinine at the end of the treatment in both groups(P0.05),but levels of cystatin C were decreased drastically(P0.01);levels of urine microalbumi,α1-microglobulin and urineβ2-microglobulin,were reduced obviously(P0.01),and the reductions of combined treatment group were more evident(P0.01).Conclusion Sulodexide combined with irbesartan,compared with irbesartan alone,can more effectively lower proteinuria level and protect renal function of senile hypertensive patients.