Pathogen distribution and antibiotic resistance among 586 septicemia patients

Objective To investigate the distribution and drug resistance among patients with septicemia to improve the clinical diagnosis and treatment.Methods Pathogen distribution and drug resistance among 586 patients from January 2002 to April 2007 were retrospectively studied.Results Totally 613 strains of bacteria were isolated,including 426 strains of Gram-positive bacteria(69.5%),163 strains of Gram-negative bacteria(26.6%)and 24 strains of fungi(3.9%).The most common pathogens were Staphylococcus epidermidis(24.5%),Staphylococcus aureus(23.2%),Escherichia coli(8.3%),Corynebacterium(5.9%),and Streptococcus(5.7%).In child patients,the infection ratio of Gram-positive bacteria was 78.7%,higher than in adults(55.7%).Various resistances to all detected antibiotics were found among the bacteria isolated.Drug resistance test showed Vancomycin was the most sensitive to Gram-positive bacteria,and carbapenem most sensitive to Gram-negative bacteria.Conclusion Gram-positive bacteria remain the most common pathogens among patients with septicemia and multi-drug resistance was presented by these bacteria.Proper antibiotics should be selected according to antibiotic sensitivity tests for improving the curing rates of infection.