Clinic institute of vasodilator function in patients with coronary heart diseases by ultrasonic

Objective To explore the endothelium-dependent and endothelium-independent vasodilator changes in coronary heart disease(CHD).Methods A non-invasive high-resolution ultrasound was used to detect the dilation changes of brachial arteries during reactive hyperemia and after sublingual nitroglycerin.Results Flow-mediated dilation(FMD)(3.68±1.91%) and nitroglycerin-mediated dilation of brachial arteries(NMD)(16.33±3.33%)in Patients with CHD were much reduced compared with control group(6.37±3.59% vs 23.31±6.63) showd significantly reduced endothelium-dependent and endothelium-independent vaso-dilator function as compared with normal subjects.FMD was inversely associated with LDL and brachial artery size(r=-0.377,P0.05;r=-0.422,P0.05),NMD was inversely associated with LDL-C and brachial artery size(r=-0.386,P0.05)by linear stepwise regression analysis.Conclusion Both endothelium-dependent and endothelium-independent vasodilation is impaired in patients with coronary heart disease.Ultrasonic measure brachial artery dilation was promising technique to diagnosis and therapy of CHD.