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2010•Journal of Shenyang Medical CollegeRequires access

Study on the Impact of CD4~+CD25~+ Regulatory T Cells on the Progression of Hepatitis C Virus Infection

Ying Liu

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Abstract

Objective:To investigate the expression of peripheral blood CD4+CD25+ regulatory T cells in patients with hepatitis C and its relationship with progression of disease.Methods:Technique of flow cytometry was used to detect peripheral blood CD4+CD25+ regulatory T cells of 69 patients with Hepatitis C and 23 controls.Results:The percentage of CD4+CD25+ regulatory T cells was significantly higher in patients with hepatitis C than those in healthy controls(P0.01).The chronic hepatitis C group had a higher percentage of CD4+CD25+ regulatory T cells than that of asymptomatic carrier(P0.05)and the group of patients with liver cirrhosis had a higher percentage of CD4+CD25+ regulatory T cells than that of chronic hepatitis C group(P0.05).Conclusion:Peripheral blood CD4+CD25+ regulatory T cells levels are correlated with the progression of HCV infection.

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What this paper is about

Objective:To investigate the expression of peripheral blood CD4+CD25+ regulatory T cells in patients with hepatitis C and its relationship with progression of disease.Methods:Technique of flow cytometry was used to detect peripheral blood CD4+CD25+ regulatory T cells of 69 patients with Hepatitis C and 23 controls.Results:The percentage of CD4+CD25+ regulatory T cells was significantly higher in patients with hepatitis C than those in healthy controls(P0.01).The chronic hepatitis C group had a higher percentage of CD4+CD25+ regulatory T cells than that of asymptomatic carrier(P0.05)and the group of patients with liver cirrhosis had a higher percentage of CD4+CD25+ regulatory T cells than that of chronic hepatitis C group(P0.05).Conclusion:Peripheral blood CD4+CD25+ regulatory T cells levels are correlated with the progression of HCV infection.

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Available abstract

Objective:To investigate the expression of peripheral blood CD4+CD25+ regulatory T cells in patients with hepatitis C and its relationship with progression of disease.Methods:Technique of flow cytometry was used to detect peripheral blood CD4+CD25+ regulatory T cells of 69 patients with Hepatitis C and 23 controls.Results:The percentage of CD4+CD25+ regulatory T cells was significantly higher in patients with hepatitis C than those in healthy controls(P0.01).The chronic hepatitis C group had a higher percentage of CD4+CD25+ regulatory T cells than that of asymptomatic carrier(P0.05)and the group of patients with liver cirrhosis had a higher percentage of CD4+CD25+ regulatory T cells than that of chronic hepatitis C group(P0.05).Conclusion:Peripheral blood CD4+CD25+ regulatory T cells levels are correlated with the progression of HCV infection.

Key concepts: IL-2 receptor, Flow cytometry, Medicine, Asymptomatic, Asymptomatic carrier, Cirrhosis, Immunology, Hepatitis C virus

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Study on the Impact of CD4~+CD25~+ Regulatory T Cells on the Progression of Hepatitis C Virus Infection — Research Paper | ScholarLens