2013•Dongwu yingyang xuebaoRequires access

Phosphatidylinositol 3-Kinase/Serine-Threonine Kinase Signaling Pathway and Its Regulation Mechanisms in Muscle Growth and Development

Yong Zhang

Abstract

Phosphatidylinositol 3-kinase/serine-threonine kinase(PI3K/Akt) is a kind of kinases which specifically catalyzes phosphatidylinositol.PI3K/Akt signaling pathway is one of the most important signaling pathways in cells and it is implicated in a broad spectrum of cell metabolism in animals.This review summarized characteristics and activation mechanism of PI3K/Akt signaling pathway,and discussed the regulation mechanisms in cell apoptosis and muscle growth and development.

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Key concepts: Phosphatidylinositol, PI3K/AKT/mTOR pathway, Protein kinase B, AKT1, Cell biology, Kinase, Signal transduction, Phosphorylation