rhG-CSF Administration Starting in 24hs After Chemotherapy or when Haematological Toxicity Occurs:A Comparative Study

Objective To study the clinical effective of rhG CSF administrated in 24hs after chemotherapy or when heamatological toxicity occurs.Methods A randomized single blind clinical trial was conducted.160 patients were enrolled into group A and B.In group A,rhG CSF was given 75 ug a day s.c. starting in 24hs after chemotherapy for 3 days,and in group B,rhG CSF starting only when heamatological toxicity degree Ⅱ occured.Results In group A,WBC and ANC decreased slowly and maintained shortly,chemotherapy delayed rate and delayed time were shorter.There was no significant difference in side effect between the two groups( P 0.05).Conclusion It can alleviate WBC and ANC decrease degree and shorten the continued time and guarantee next chemotherapy cycle to go on smoothly when G CSF is given in 24hs after chemotherapy.