Clinical study of major depression comorbid with anxiety

ObjectiveTo investigate the prevalence of anxiety disorder comorbidity in major depression,and study the impacts of comorbidity on symptoms, course and prognosis of major depression.MethodsOne hundred and twenty-five outpatients were assessed by HAMD, HAMA, CGI-SI and SDSS,and treated by SSRIs.Three month later, 87 patients were assessed by HAMD, HAMA, CGI and SDSS again. Results39.2% of patients were coexistence of anxiety disorders, 20.0% for general anxiety disorder, 12.8% for panic disorder. Compared with patients without anxiety, patients with anxiety had higher scores in HAMD, HAMA, CGI and SDSS in baseline and three months later,there was significant difference between two group(P0.05). ConclusionThe coexistence of anxiety and depression in the clinical setting was quite common; The patients comorbid with anxiety had more severe symptoms and social function impairment, and their anxiety symptom was more difficult to recover.