2001•Journa of Henan Medical UniversityRequires access

Expression of matrix metalloproteinase-2 mRNA in human esophageal carcinoma tissue

Hongtao Wen

Abstract

Aim:To investigate the expression of matrix metalloproteinase 2(MMP 2) mRNA in esophageal carcinoma.Methods:Tumor tissues and adjacent normal tissues in 41 cases of esophageal carcinoma were studied by using the reverse transcriptase polymerase chain reaction(RT PCR).Results:The expression rate of MMP 2 mRNA in tumor tissues was significantly higher than that in adjacent tumor tissues( P 0.05),and it was so as in esophageal carcinoma with lymph node metastasis and that without metastasis( P 0.05).Conclusion: MMP 2 may play an important role in tumor invasion and metastasis in esophageal carcinoma.

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Key concepts: Matrix metalloproteinase, Carcinoma, Metastasis, Messenger RNA, Lymph node metastasis, Pathology, Reverse transcription polymerase chain reaction, Medicine