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2005•Journal of Northwest Normal UniversityRequires access

Studies on antitumor activity diterpenoids from Isodon excisoides

Kun Sun

Open publisher page 2 citations

Abstract

Five ent-kaurane diterpenoids were obtained from the dried leaves of Isodon excisoides((Sun ex C.H.Hu)C.Y.Wu et H.W.Li)distributed in Gansu Province.Their structures were identified as Kamebacetal-A(Ⅰ),Glaucocalyxin-A(Ⅱ),Kamebanin(Ⅲ),Wangzaozin-A(Ⅳ)and Leukamenin-E(Ⅴ)by spectroscopic means,respectively.The cytotoxicity was tested in vitro by SRB assay.The results indicate that the five compounds showed significant cytotoxic activity against BEL-7402 and HO-8910 cell lines.

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What this paper is about

Five ent-kaurane diterpenoids were obtained from the dried leaves of Isodon excisoides((Sun ex C.H.Hu)C.Y.Wu et H.W.Li)distributed in Gansu Province.Their structures were identified as Kamebacetal-A(Ⅰ),Glaucocalyxin-A(Ⅱ),Kamebanin(Ⅲ),Wangzaozin-A(Ⅳ)and Leukamenin-E(Ⅴ)by spectroscopic means,respectively.The cytotoxicity was tested in vitro by SRB assay.The results indicate that the five compounds showed significant cytotoxic activity against BEL-7402 and HO-8910 cell lines.

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OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Five ent-kaurane diterpenoids were obtained from the dried leaves of Isodon excisoides((Sun ex C.H.Hu)C.Y.Wu et H.W.Li)distributed in Gansu Province.Their structures were identified as Kamebacetal-A(Ⅰ),Glaucocalyxin-A(Ⅱ),Kamebanin(Ⅲ),Wangzaozin-A(Ⅳ)and Leukamenin-E(Ⅴ)by spectroscopic means,respectively.The cytotoxicity was tested in vitro by SRB assay.The results indicate that the five compounds showed significant cytotoxic activity against BEL-7402 and HO-8910 cell lines.

Key concepts: Cytotoxicity, Stereochemistry, Chemistry, Cytotoxic T cell, Traditional medicine, In vitro, Terpene, Biochemistry

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