Effect of penehyclidine hydrochloride on stress reaction during cardiopulmonary bypass in patients undergoing open heart surgery

Objective To observe the effect of penehyclidine hydrochloride(PHC) on stress reaction during cardiopulmonary bypass in patients undergoing open heart surgery.Methods Forty patients undergoing heart valve replacement with cardiopulmonary bypass were randomly divided into two groups with 20 cases each:penehyclidine hydrochloride group(group P) and control group (group C) respectively.Patients in group P were injected PHC 0.05 mg/kg 10 min before CPB from the internal jugular vein.Patients in group C were injected the same volume saline.Jugular vein blood was drawn following 6 time points:before CPB(T_1),10 min after aortic cross clamp release(T_2), immediately at the end of CPB(T_3),2 h after operation(T_4 ),6 h after operation(T_5),18 h after operation(T_6).The density of blood cytokine levels(IL-6,IL-10) were detected by enzyme-linked immunosorbent assay.Blood samples were taken for analysis of blood gas,serum glucose and lactate concentration at every time point.Results In group P,the concentrations of blood glucose and lactate were significantly lower at T_2,T_3,T_5 than those in group C(P 0.05).In group P,the concentration of IL-6 was significantly lower at T_3-T_5 than those in group C(P0.05). Conclusion 0.05 mg/kg penehyclidine hydrochloride preconditioning before CPB could depress stress reaction by regulating nervous system,endocrine system and immunity system.