Recent efficency of water mitigation project on endemic arsenic poisoning

Objective To compare the DNA oxidative injuries of people exposed to arsenic in drinking water before and after water mitigation project for one year.Methods People exposed to arsenic in drinking water were selected in Gangfangying village,inner Mongolia.The skin lesions induced by arsenic were compared;The concentrations of total arsenic,inorganic arsenic,monomethylarsonic acid and dimethylarsinic acid of urine,the levels of urine 8-hydroxy-2'-deoxyguanosine(8-OH-dG)were measured by AAS and ELISA,respectively.Results The skin lesions induced by arsenic were improved markedly after water mitigation project for one year;The concentrations of total arsenic,inorganic arsenic,monomethylarsonic acid,dimethylarsinic acid of urine and the levels of urine 8-OH-dG all decreased significantly.Conclusion Water mitigation project was an effective intervention method in endmic arsenic areas.Skin lesions of people exposed to arsenic in drinking water were improved and their DNA oxidative injuries decreased after one year water mitigation.