Effects of Jinmaitong capsule on NOS expression in penile tissue of diabetic rats

Objective To investigate the effect of Jinmaitong capsule on NOS expression in penile tissue of diabetic rats.Methods The diabetic model rats were established by intraperitoneal injection of streptozotocin(60mg·kg-1),and were randomized to model group,neurotropin group,Jinmaitong low-dose group,Jinmaitong mid-dose group,Jinmaitong high-dose group,matched with age-matched non diabetic rats of normal group.Model group and normal group were administrated with distilled water.All rats were administrated daily by gavage and sacrificed at the end of the 16th week.Neuronal nitric oxide synthase(nNOS) expression of penile nerve fibers and inducible nitric oxide synthase(iNOS) expression of penile smooth muscle cells were detected by immunohistochemical staining.Results Compared with the normal group,the nNOS expression of model group decreased significantly(P0.01).Compared with the model group,Jinmaitong low-dose group,Jinmaitong high-dose group and neurotropin group showed no significant difference in nNOS expression(P0.05).Compared with the model group or neurotropin group,Jinmaitong mid-dose group showed significantly increase in nNOS expression(P0.01).iNOS expression showed no significant difference between all groups(P0.05).Conclusions Jinmaitong capsule can improve the reduction of nNOS expression of penile nerve fibers in diabetic rats.