EFFECTS OF BFGF ON THE ACTIVITIES OF NA~+-K~+-ATPASE AND CA~(2+)-MG~(2+)-ATPASE IN BRAIN AND LIVER TISSUE OF RAT MODEL OF ALCOHOLISM

[Objective]To study the effects of basic fibroblast growth factor(bFGF)on the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in brain and liver tissue of rat model of alcoholism.[Methods]The rat model of alcoholism was established by perfusing stomach with alcohol.Wistar rats were randomly divided into of model of control group,model of alcoholism Group,normal saline(NS)and bFGF treatment group.The activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in brain and liver tissue were detected.[Results]The activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in brain and liver tissue were significantly decreased than those in control group(P﹤0.05).After bFGF intervention,the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in brain and liver tissue of the bFGF group were significantly increased compared with the NS control group and model of alcoholism group respectively(P﹤0.05).[Conclusion]bFGF can increase the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in brain and liver tissue in alcoholism model rats.The bFGF can protect alcoholic brain damage and liver damage in rats.