transcatheter arterial chemoembolization(TACE)combined with super gamma knife stereotaxis radiation therapy for primary hepatic carcinoma

Objective:To evaluate the effects of transcatheter arterial chemoembolization(TACE)super gamma knife stereotaxis radiation therapy combined with in treatment of primary hepatic carcinoma.Methods:Twenty-four of 46 patients with primary hepatic carcinoma were treated with transcatheter arterial chemoembolization(TACE)combined with super gamma knife stereotaxis radiation therapy.Twenty-two of 46 patients with primary hepatic carcinoma were treated with TACE only.The patients received hepatic arterial infusion chemotherapy including 5-fluorouracil 1000mg,epirubicin 40mg-80mg,mitomycin 10mg-20mg,embolization with iodized oil 10ml-30ml.Super gamma knife stereotaxis radiation therapy was performed with technique of stereotaxis radiation therapy(SRT).Planning of treatment from 3 to10 dots,3Gy-6Gy per-fraction,2-5 times per week,and the total treatment dose was 30Gy-50Gy.Resulis:The efficiency rate(CR+PR)of super gamma knife combined with TACE group was 70.8%,and the TACE alone group was 45.5%(P0.05).The 1-year survival rate of super gamma knife combined with TACE group was 66.7%,and that of the TACE alone group was 54.5%(P0.05).Conciusion:Super gamma knife combined with TACE is an effective approach in the treatment of primary hepatic carcinoma.