The significance of Llmph node micrometastasis in gastric cancer

Objective:The study was designed to investigate the significance of micrometastasis in gastric carcinoma.Methods:The metastasis and micrometastasis in lymph node were determined by routine HE and immunohistochemistry assay.Results:Of the 100 patients, there were 76 patients with lymph node metastasis, 6 patients with micrometastasis and 18 patients with no lymph node metastasis. In the expression of P27 Kip1 protein?P53 protein and 5 year survival rate, the group of lymph node metastasis had statistic significance (P0.05) to on group of lymph node micrometastasis. On the contrary, the group of lymph node micrometastasis had no statistic significance(P0.05) on the group of lymph node without metastasis.Conclusions:The lymph node metastasis in gastric carcinoma had little influence to the expression of P27 Kip1 protein?P53 protein and 5 year survival rate. The method was sensitive to the assay of micrometastasis in lymph node of gastric carcinoma by immunohistochemistry, but there was little significance in therapy and prognosis.