Efficacy of Tolterodine combined with Nifedipine in female patients with overactive bladder

Objective To evaluate the efficacy of Tolterodine combined with Nifedipine in female patients with overactive bladder(OAB).Methods 60 female patients with OAB were randomly divided into two groups with 30 patients.Patients in Group A received tolterodine 2 mg bid for 4 weeks.Patients in Group B received Tolterodine combined with Nifedipine 5 mg tid for 4 weeks.During the treatment all patients recorded voiding and adverse reactions in a diary.The symptoms of urgency,frequency and incontinence were evaluated with OABSS scores at the beginning and the end of the therapy period.The results of the efficacy were analyzed with SPSS 13.0.Results The OABSS scores at the beginning and the end of therapy for the two groups were significantly different(P0.01).The OABSS scores at the end of the therapy between the two groups were significantly different(P0.05).Patients in Group B had better results than patients in Group A.Conclusion Tolterodine combined with Nifedipine is more effective than Tolterodine alone in the treatment of female OAB.