Influence of serum HBV DNA level in pregnant women with HBV infection on the effect of blocking mother-to-infant transmission by passive-active immunoprophylaxis

Objective:To explore the influence of serum HBV DNA level in pregnant women with HBV infection on the effect of blocking mother-to-infant transmission by passive-active immunoprophylaxis.Methods:Fifty-three pregnant women with HBV infection and their babies were divided into three groups according to serum HBV DNA level in pregnant women,including 106 copies/ml group,103~106 copies/ml group and 103 copies/ml group.All neonates adopted 200 U HBIG injection at birth and 1 month,and 20 microgramme HBV vaccine injection at birth,1 month and 6 month,respectively.Venous blood from pre-delivery pregnant women and babies at birth,12 month were collected in order to detect serum HBV markers and the level of HBV DNA.Results:There were no significant difference in level of serum HBsAg among the three groups(P0.05).Serum HBeAg positive rate and titer in 106 copies/ml group were significantly higher than those in 103~106copies/ml group and 103 copies/ml group(P0.05).The level of serum HBV DNA in 53 neonates was below the detecting limit(1 000 copies/ml).Serum HBsAg positive rate in 53 neonates was 9.4%(5/53),and there were no significant differences among the three groups(P0.05).As the serum HBV DNA level was elevated,the positive rate and titer of serum HBeAg in neonates also became higher,but those of serum anti-HBe in neonates became lower gradually(P0.05).When the babies were 1 years old,serum HBsAg and HBeAg were entirely negative,and serum HBV DNA was also below the detective limit.The level of serum anti-HBs in 106 copies/ml group was significantly lower than that in 103~106 copies/ml group and 103 copies/ml group,respectively(P=0.021;P=0.011)Conclusion:High level of serum HBV DNA in pregnant women has influence on the effective rate of blocking HBV mother-to-infant transmission.