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2003•Acta Academiae Medicinae ZunyiRequires access

Experimental study of inhibitory effect of huobahuagen tablet on airway inflammation in guinea pigs with asthma

Jiang Zhao

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Abstract

Objective To investigate inhibitory effect of Huobahuagen tablet (HBHG)on airway inflammation in guinea pigs with asthma. Methods Guinea pigs model of asthma was established. Male guinea pigs were randomly divided into two groups:the control(n=8), the HBHG (n=9). Bronchoalveola lavage fluid (BALF) was measured at the numbers of total cells,eosinophil,lymphocyte and neutrophils and the concentration of protein.The mean thickness of airway wall and glands was determined by contour tracing ,using a digitizing pad and microcomputer . Results The numbers of total cells, eosinophil , lymphocyte and neutrophils and the concentration of protein in BALF from HBHG group were significantly lower than those from control group (P0.01). The mean thickness of a irway wall and glands in HBHG group were thinner than those of the control respectively (P0.01). Conclusions This results showed that HBHG may inhibit airway inflammation in guinea pigs with asthma . [

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Objective To investigate inhibitory effect of Huobahuagen tablet (HBHG)on airway inflammation in guinea pigs with asthma. Methods Guinea pigs model of asthma was established. Male guinea pigs were randomly divided into two groups:the control(n=8), the HBHG (n=9). Bronchoalveola lavage fluid (BALF) was measured at the numbers of total cells,eosinophil,lymphocyte and neutrophils and the concentration of protein.The mean thickness of airway wall and glands was determined by contour tracing ,using a digitizing pad and microcomputer . Results The numbers of total cells, eosinophil , lymphocyte and neutrophils and the concentration of protein in BALF from HBHG group were significantly lower than those from control group (P0.01). The mean thickness of a irway wall and glands in HBHG group were thinner than those of the control respectively (P0.01). Conclusions This results showed that HBHG may inhibit airway inflammation in guinea pigs with asthma . [

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Available abstract

Objective To investigate inhibitory effect of Huobahuagen tablet (HBHG)on airway inflammation in guinea pigs with asthma. Methods Guinea pigs model of asthma was established. Male guinea pigs were randomly divided into two groups:the control(n=8), the HBHG (n=9). Bronchoalveola lavage fluid (BALF) was measured at the numbers of total cells,eosinophil,lymphocyte and neutrophils and the concentration of protein.The mean thickness of airway wall and glands was determined by contour tracing ,using a digitizing pad and microcomputer . Results The numbers of total cells, eosinophil , lymphocyte and neutrophils and the concentration of protein in BALF from HBHG group were significantly lower than those from control group (P0.01). The mean thickness of a irway wall and glands in HBHG group were thinner than those of the control respectively (P0.01). Conclusions This results showed that HBHG may inhibit airway inflammation in guinea pigs with asthma . [

Key concepts: Guinea pig, Eosinophil, Airway, Asthma, Medicine, Immunology, Ovalbumin, Inflammation

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