2007•Journal of Shantou University Medical CollegeRequires access

Relationship between the Apolipoprotein E Promoter Polymorphisms and the Risk of Age-related Macular Degeneration

Yan Yi-nong

Abstract

Objective: To study the relationship between apolipoprotein E(APOE)promoter(-219G/T)polymorphisms and the risk of age-related macular degeneration(AMD).Methods: APOE-219G/T genetype in AMD group(50 cases)and control group(95 persons)was identified by polymerase chain reaction and restriction fragment length polymorphism genotyping technique.Results: No significant difference was found between two groups on the distribution of APOE-219G/T genotype.Conclusion: The APOE-219G/T polymorphisms do not contribute to AMD risk.

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Key concepts: Apolipoprotein E, Genotyping, Macular degeneration, Genotype, Promoter, Genetics, Apolipoprotein B, Polymerase chain reaction