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[Effects of losartan on renal ultrastructure in diabetic rats].

Zhoung Hj, Zhang Dm, Muqing Zhou

Abstract

OBJECTIVE: To observe the effects of losartan on renal ultrastructure in streptozotocin diabetic rats. METHODS: Male SD rats were randomly divided into 2 groups: normal control group (NC group) and diabetic group. Diabetic group was induced by streptozocin (65 mg.kg-1) abdominal injection. Four weeks later, diabetic rats were further divided into 2 groups: diabetic rats treated with losartan (DL group, 20 mg.kg-1.d-1, by gavage) and diabetic unteated control group (DC group). Renal ultrastructure of each group was observed before and after 12 weeks of treatment respectively. RESULTS: The ultrastructure alterations in DL group including mesangial expansion and thickening of glomerular basement membrane (GBM), were lighter than those in DC group. CONCLUSION: Losartan can prevent renal pathological progress in diabetic rats. It is suggested that losartan may have some renal protective effects.

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Key concepts: Losartan, Glomerular basement membrane, Streptozocin, Streptozotocin, Medicine, Internal medicine, Endocrinology, Ultrastructure